We are working in the most exciting areas of medicinal chemistry with special focus to the structure-based drug design and discovery, targeting human kinases. In our lab, the three-dimensional structure of potential drug targets  and their complexes with inhibitors are determined by X-ray crystallography. The structural features of kinases are exploited to design high-affinity selective inhibitors that bare minimum side effects, using a combination of cutting-edge experimental, computational, molecular, and cellular biology methods. Our research also involved the experimental investigations of protein folding pathways, global and local stabilities of proteins, and their conformation, which are required for the development of novel molecules that may be further employed to reduce the protein aggregates.